Endocrine Abstracts

Daidzein, one of the main phytoestrogens of soy, is able to act as estrogen-like compounds due to its structural similarity with 17β-estradiol, which gives them the capacity to bind estrogen receptors and to induce hormone-like effects. Considering, that somatotropic system is sensitive to sex steroids, the aim of this study was to investigate the effects of daidzein on stereological and biochemical parameters of pituitary somatotropic (GH) cells in orchidectomized adult ...

The different response of somatotropic system to genistein and daidzein in the rat hypothalamus: Svetlana Trifunović, Branka Šošić-Jurjević, Milica Manojlović-Stojanoski, Nataša Ristić, Nataša Nestorović, Branko Filipović, Verica MiloševićUniversity of Belgrade, Institute for Biological Research ‘Siniša Stanković’, Department of Cytology, Belgrade, Serbia The different r...

Glucocorticoids affect the growth and maturation of fetal organ systems, but overexposure to exogenous glucocorticoids retard fetal growth and may alter developmental process in sensitive tissues. On the other hand, fetal ovary is not characterized by definitive follicular structure, but the clusters of germinative cells are predominant. Germ cells may be in meiotic prophase or with sign of degeneration.The aim of this study was to determine whether pren...

Thyroid C cells produce bioregulatory peptid calcitonin (CT), which lowers plasma calcium (Ca) and acts as an inhibitor of bone resorption. In this study we investigated the effects of tamoxifen, as a selective estrogen receptor modulator on thyroid C cells and skeletal changes in middle-aged orchidectomized (Orx) rats as an animal model of male osteoporosis. Fifteen-month-old male Wistar rats were divided into Orx and a sham-operated (SO) groups. Two weeks after gonadectomy, ...

Obesity, a major public health problem, is associated with hypercholesterolemia and other metabolic disorders, which are potent risk factors for athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute significantly to prevention and treatment of modifiable risk factors. Consumption of purified soybean isoflavones was reported to reduce plasma and liver cholesterol levels. The precise mechanism has...